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KMID : 0370219860300040169
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Yakhak Hoeji
1986 Volume.30 No. 4 p.169 ~ p.173
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A Sutdy on the Mechanism of Analgesic Action of Piperine
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Abstract
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It was carried out to detect the analgesic action of piperine by hot-plate method and to elucidate its mechanism in rats. Piperine (30mg/kg i.p.) produced profound analgesia, which was blocked by naloxone (10mg/kg). Chronic intraperitoneal administration of piperine significantly increased the contents of p-endorphin in rat midbrain. In the chronic piperine-treated groups, significant decreases of maximum opiate binding were observed. However, Kd value in these groups were not changed.
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